The country's innovative development guarantees the trustworthy capacity of future periods. In Kazakhstan, spatial development of regional territories is relevant for academic circles and the business community. The basis of this study is whether Kazakhstan has the potential to form a scientific and technical direction of development in the presence of existing opportunities for the dynamic development of regions. In this study, such scientific methods as analysis and synthesis, generalization, as well as an integrated approach, analytical review, abstraction, and logical analysis were used. The analysis showed that not all regions of Kazakhstan have positive changes: the number of research institutes is decreasing, and the number of research specialists performing R&D does not increase. However, we can note a sharp growth rate in the number of enterprises, as well as the implementation of R&D in terms of high investment activity in the country. In this regard, we note that the preparation of Kazakhstan to become one of the best states in terms of competitiveness is based on long-term planning to increase the position of innovation vitality of organizations, upgrade the innovation climate in the country, increase the share of investments in scientific modernization and convergence of business and science. Thus, the main outcomes of this research show that regional differences in economic development illustrate the uniqueness of conditions for each of them, the development of which shows positive dynamics and changes. The innovative trail of development of Kazakhstan is at an early stage. However, the accumulated experience of this country can rightfully be considered an example for many other countries.